Tag Archives: alpha-synuclein

Advancing age and risk for Parkinson’s disease

I read an interesting review article recently, by Dr Reeve and colleagues in Ageing Research Reviews (14(2014) 19-30) that focused on the age-related changes to neurones in the brain that cause motor symptoms in Parkinson’s disease (PD).   The authors state that aging is important for the development of PD, which makes sense since 1% of adults 60+years are affected… Read more »

promising biomarker for parkinson’s disease: PPMI results

Parkinson’s disease is typically characterized in a clinical setting by the present of tremor, rigidity, bradykinesia (slow movement), and in the later stages, postural instability (balance). Researchers from the University of Pennsylvania report ( JAMA Neurology) that the appearance of proteins in the spinal fluid may be the key to identifying affected patients early in the disease process, long before symptoms set in…. Read more »

slowing Parkinson’s progression: a research update

alpha-synuclein is a protein encoded by the SNCA gene. Although we are still not certain of what it does, we do know it makes up Lewy Bodies, clusters of proteins that are a pathological hallmark of Parkinson’s disease and other dementias (lewy body dementias). It is thought that in Parkinson’s disease, the variability in alpha-synuclein gene produces either too much alpha-synuclein protein… Read more »

From research to real life: smell, sleep, constipation and Parkinson’s

… what do these 3 things have in common? Early detection of PD. New research shows that hyposmia (loosing sense of smell), rapid eye movement sleep behavior disorder (RBD), and constipation, may be early Parkinson’s disease manifestations that reflect the underlying alphasynuclein pathology (the degeneration that is happening in the brain!) as well as predict subsequent onset of motor manifestations (Ravina &… Read more »

from research to real life – curcumin attacks proteins related to Parkinson’s disease

Curcumin is a natural compound in the Indian spice, Turmeric, part of the ginger family. The main idea: In Parkinson’s disease, abnormal clumping of the protein alpha-synuclein occurs. New research shows curcumin may bind to the alpha-synuclein proteins and prevent the abnormal folding and clumping that may be the first steps to Parkinson’s disease. – Research: Curcumin prevents aggregation in α-synuclein… Read more »

from research to real life – calcium may advance Parkinson’s disease

I’m starting a new regular post… from research to real life. There’s so much information out there, it’s hard to keep track of it all! I will present new (and exciting!) research in both a scientific and news media format, so the ideas come across in whatever way you choose to get your information! I thought this was an interesting article… Read more »